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KMID : 0869020060090020116
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Journal of Korean Orthopaedic Research Society
2006 Volume.9 No. 2 p.116 ~ p.123
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Periosteum-Derived Mesenchymal Stem Cells and Scaffolds Transplanted into Long-Bone Defects of Rabbit
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Kim Hui-Taek
Kang Dong-Joon
Kang Jeong-Han
Lee Jong-Seo
Chang Hee-Kyung
Park Soon-Mi
Yoo Chong-Il
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Abstract
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Purpose : To observe the changes in periosteum-derived mesenchymal stem cells and different scaffold materials transplanted into rabbit long-bone defects.
Materials & Methods : Thirty-five white rabbits were grouped according to the material transplanted into their tibial bone defects: Group 1 (control group); Group 2-A (agar plus mesenchymal stem cells); Group 2-B (agar only); Group 3-A (Biocompatible Osteoconductive Polymer plus mesenchymal stem cells); Group 3-B (BOP® only); Group 4-A (xenograft plus mesenchymal stem cells); Group 4-B (xenograft only). After surgery, radiologic and microscopic observation were performed weekly for 8 weeks.
Results : Rabbits transplanted with mesenchymal stem cells showed better bone formation than those without. Mesenchymal stem cells transplanted with agar had better results than mesenchymal stem cells plus BOP®.
Rabbits receiving xenografts showed severe inflammatory reactions.
Conclusion : Further research is needed on rigid scaffold materials which minimize immune reaction, and on how to ensure uniform distribution of mesenchymal stem cells within such materials.
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KEYWORD
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Bone formation, Mesenchymal stem cell, Scaffold
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